Region Östergötland


Omega 3 fetter och Lactobacillus reuteri och allergiutveckling hos barnet

Original arbeten 

1. Yu G, Duchén K, Björkstén B. Fatty acid composition in colostrum and mature milk from non-atopic and atopic mothers during the first 6 months of lactation. Acta Paediatr  1998;87: 729-36.

2. Duchén K, Yu G, Björkstén B. Atopic sensitisation during the first year of life in relation to long chain polyunsaturated fatty acid levels in human milk. Pediatr Res 1998; 44:478-484.

3. Duchén K, Yu G, Björkstén B. Polyunsaturated fatty acids in breast milk in relation to atopy in the mother and her child. Int Arch Allergy Immunol 1999; 118:321-23

4. Duchén K, Casas R, Fagerås-Böttcher M, Yu G, Björkstén B. Human milk polyunsaturated long chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy. Pediatr Allergy Immunol, 2000; 11: 29-39.

5. Abrahamsson TR, Jakobsson T, Böttcher MF, Fredrikson M, Jenmalm MC, Björkstén B, Oldaeus G. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119:1174-80.

6. Böttcher MF, Abrahamsson TR, Fredriksson M, Jakobsson T, Björkstén B. Low breast milk TGF-beta2 is induced by Lactobacillus reuteri supplementation and associates with reduced risk of sensitization during infancy. Pediatr Allergy Immunol. 2008;19:497-504.

7. Abrahamsson TR, Sinkiewicz G, Jakobsson T, Fredrikson M, Björkstén B. Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life. J Pediatr Gastroenterol Nutr. 2009;49:349-54

8. Furuhjelm C, Warstedt K, Larsson J, Fredriksson M, Fagerås-Böttcher M, Karin Fälth-Magnusson K, Duchén K. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Pediatr 2009; 98:1461-7.

9. Warstedt K, Furuhjelm C, Duchén K, Fälth-Magnusson K, Fagerås Böttcher M. The effects of omega-3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion. Warstedt K, Furuhjelm C, Duchén K, Fälth-Magnusson K, Fagerås M. Pediatr Res. 2009; 66:212-7

10. Furuhjelm C, Warstedt K, Fagerås-Böttcher M, Karin Fälth-Magnusson K,Larsson J, Fredriksson M, Duchén K. Allergic disease in children up to two years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr Allergy Immunol 2011;22:505-14

11. Furuhjelm C, Jenmalm M, Duchén K. Th1 and Th2 chemokines, vaccine induced immunity and allergic disease in infants after maternal ω-3 fatty acid supplementation during pregnancy and lactation. Ped Research. 2011;69:259-64

12. Abrahamsson TR, Sandberg Abelius M, Forsberg A, Björkstén B, Jenmalm MC. A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization. Clin Exp Allergy. 2011;41:1729-39

13. Abrahamsson TR, Jakobsson HE, Andersson AF, Björkstén B, Engstrand L, Jenmalm MC. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012;129:434-40,

14. Warstedt K, Duchén K. Decreased proportions of linoleic acid (LA) in cord blood phospholipids in Swedish children between 1985 and 2005. Submitted to Eur J Nutr. 2012 May 15. [Epub ahead of print]


Vetenskapliga sammafattningar

1. Polyunsaturated n-3 fatty acids and the development of atopic disease. Duchén K, Björkstén B. Lipids 2001, 36:1033-1042.

2. Are human Milk polyunsaturated fatty acids (PUFA) related to atopy in the mother and her child? Duchén K. Allergy 2001, 56:587-92.

3. Timing of allergy-preventive and immunomodulatory dietary interventions – are pre-natal, perinatal or post-natal strategies optimal? Jenmalm M, Duchen K. Accepted in Clin Exp Allergy.


Medicinska avhandlingar

1. Human milk factors and atopy in early childhood. Karel Duchén 1999.

2. Can Lactobacillus reuteri prevent allergic disease in early childhood? Thomas Abrahamsson, 2009.

3. Polyunsaturated fatty acids, maternal and infant immune responses and allergic disease in infancy. Kristina Warstedt 2010.

4. Can Fish oil in pregnancy and lactation alter maternal and infant immunological responses and prevent allergy in the offspring? Catrin Furuhjelm, 2010.